A 51-Year Old Woman with Schnitzler Syndrome Treated with Canakinumab
نویسندگان
چکیده
Schnitzler syndrome is a rare auto-inflammatory disorder characterized by urticarial skin rash, a monoclonal IgM component and at least two of the following findings: periodic fever, arthralgias or arthritis, bone pain, palpable lymph nodes, liver or spleen enlargement, elevated erythrocyte sedimentation rate, leukocytosis, and abnormal findings on bone morphologic investigations. We present the first case of Schnitzler syndrome successfully treated with Canakinumab, a novel anti-IL-1-beta monoclonal antibody.
منابع مشابه
Schnitzler syndrome, a rare autoinflammatory disease. Complete response to IL-1 blockade
The Schnitzler syndrome (SCS) is a rare, late-onset acquired autoinflammatory syndrome often underdiagnosed. The diagnosis is based on the Lipsker and recently on validated Strasbourg diagnostic criteria (chronic urticarial rash, monoclonal gammopathy, intermittent fever, arthritis, arthralgia, bone involvement, hepatomegaly, splenomegaly, lymphadenopathy, dermal infiltration of neutrophils and...
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